Chemical and electrochemical iodination studies of 6-demethyl-6-deoxytetracycline
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Chemical and electrochemical iodination studies of 6-demethyl-6-deoxytetracycline by Theresa Marie Semenuk Download PDF EPUB FB2
Complete schematic view of the 6-Demethyldeoxytetracycline's synthesis performed by Robert B. Woodward. The Chemical Development of CI and CI A Continuous Nitration, A MgCl 2 /Et 3 N-Mediated C-Alkylation of a Chloronitropyrimidine, A Catalytic Protodediazotization of a Diazonium Salt, and an Air Oxidation of an Amine.
One of the fluorocyclines, 7-fluoropyrrolidinoacetamidodemethyldeoxytetracycline (17j, also known as TP, 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Conference, Boston, MA, September, poster F1 - ), is currently undergoing phase 2 clinical trials in patients with complicated intra Cited by: Toronto.
Canada (Received 8 MaY ) ['=51]7-iododemethyldeoxytetracycline can be used in a non-invasive method to indicate sites of active bone mineralization. Sequential doses of this agent have been used to follow bone repair in a Author: Larry W.
Belbeck, B.M. Bowen, E.S. Garnett, J.K. Porter, F.W. Teare. 7-Fluoropyrrolidinoacetamidodemethyldeoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent Article in Journal of Medicinal Chemistry 55(2). Isolation and recovery of calcium chloride complex of 7-dimethylaminodimethyl ldeoxytetracycline hydrochloride.
United States Patent Chemical Abstracts, vol. 64,a relied on. The compound 7-dimethylaminodemethyldeoxytetracycline (hereinafter referred to by its generic name "minocycline") is a valuable. Request PDF | Aromatic Substitution Reactions | This chapter is concerned with reactions that introduce or replace substituent groups on aromatic rings.
The. Incyclinide is a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
USA US05/, USA USA US A US A US A US A US A US A US A US A US A Authority US United States Prior art keywords minocycline calcium chloride dimethylamino calcium ph Prior art date Legal status (The legal status is an Cited by: Addition of a dimethylamino group at C-4 (6-demethyldeoxytetracycline) is the simplest tetracycline having in vivo activity.
Also of particular interest from an SAR standpoint is the structural integrity of the "inviolate zone" encompassing C 10, C11, C12, and C 1.